反应详情

温度

190 °C

A mixture of 4-iodonitrobenzene (15 g, 0.060 mol), bromopentafluorobenzene (14.9 g, 2.56 mL, 0.060 mol) and copper powder (30 g) was placed into a 50-mL J-Young glass tube and heated at 190° C. for 24 hours. The tube was cooled and the mixture was extracted exhaustively with dichloromethane. The solvent was removed and the residue was extracted with boiling hexane and filtered while hot. The solvent was removed and the resulting viscous solid was sublimed to obtain 4-nitro-2′,3′,4′,5′,6′-pentafluorobiphenyl as a yellow solid (11.0 g, 63% yield).

1. customwas placed into a 50-mL J-Young glass tube
2. temperatureThe tube was cooled
3. extractionthe mixture was extracted exhaustively with dichloromethane
4. customThe solvent was removed
5. extractionthe residue was extracted with boiling hexane
6. filtrationfiltered while hot
7. customThe solvent was removed