Hydrochloric Acid → 4-Amino-4'-n-octyl-2',3',5',6'-tetrafluorobiphenyl

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Reaction Steps

n-Octyllithium in dry ether (9.5 mL) was added slowly to a solution of 4-amino-2′,3′,4′,5′,6′-pentafluorobiphenyl (1.5 g, 5.79 mmol, Example 9) in dry ether (100 mL) at −78° C. The solution was stirred at this temperature for 2 hours and then allowed to warm to room temperature over a period of 5 hours. Hydrochloric acid (3M, 100 mL) was added and a white solid was precipitated from the solution. The solid was filtered and dried. After sublimation, 4-amino-4′-n-octyl-2′,3′,5′,6′-tetrafluorobiphenyl was obtained as a white solid (1.2 g, 63% yield).

Provenance & Evidence