Benzyl Chloride → HCID 86600821, compound

HRID 601493Notes

Reaction equation

HRID 601493 reaction equation
[CH2:1]([Cl:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]([C:11]1([CH3:35])[CH:16]([CH3:17])[CH:15]([OH:18])[CH2:14][C:13]([CH2:20][CH3:21])([CH3:19])[N:12]1[O:22][C:23]([CH3:34])([CH3:33])[C:24]([NH:26][CH2:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])=[O:25])[CH3:10]>C(#N)C>[Cl-:8].[CH2:1]([N+:30]([CH2:29][CH2:28][CH2:27][NH:26][C:24](=[O:25])[C:23]([O:22][N:12]1[C:13]([CH2:20][CH3:21])([CH3:19])[CH2:14][CH:15]([OH:18])[CH:16]([CH3:17])[C:11]1([CH2:9][CH3:10])[CH3:35])([CH3:34])[CH3:33])([CH3:32])[CH3:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7503Benzyl ChlorideHCID 57849395HCID 57849395, compound2×

Product 1

HCID 86600821HCID 86600821, compoundYield 102.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Benzylchloride (0.87 g, 0.0069 mol) is added to a solution of 2-(2,6-diethyl-4-hydroxy-2,3,6-trimethyl-piperidine-1-yloxy)-N-(3-dimethylamino-propyl)-2-methyl-propionamide (2.2 g, 0.0057 mol, compound 110) in acetonitrile (3 ml), The mixture is stirred for 19 h at room temperature and is then evaporated. The residue is triturated with diethylether to remove the excess of benzylchloride, the solid is filtered off and dried to afford 3.0 g of the title compound as a colorless amorphous solid.

Workup

  1. customis then evaporated
  2. customThe residue is triturated with diethylether
  3. customto remove the excess of benzylchloride
  4. filtrationthe solid is filtered off
  5. customdried

Sources & evidence

ORD record
ord-1036b6627d854c37b0eef09e27bb45e1
Source dataset
uspto-grants-2011_03
Patent number
US07902368B2

Reaction notes

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