Pyrrolidine → HCID 57421475, compound

Participants

Reaction Steps

Add oxalyl chloride (11.6 g, 90.6 mmol) dropwise to a solution of 6-nitroindole (10.6 g, 65.4 mmol) in ether (100 mL). Stir at room temperature for 18 h, filter the precipitate formed, and dry. Dissolve the precipitate in CH2Cl2 (100 mL), cool to −20° C., and add pyrrolidine (16.0 mL, 191.5 mmol) dropwise. Warm to room temperature and stir for 2 h. Filter the solid from the reaction, wash several times with ether, and dry to give the title compound (8.5 g, 45%). MS (ES+) 288 (M+1)+.

Provenance & Evidence