1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine → 3-Methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine

Participants

Reaction Steps

Dissolve 1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine (1.53 g, 3.74 mmol) in THF (30 mL) and add 5% Pd/C then stir the slurry at room temperature under a hydrogen atmosphere for 3 h. Filter the black mixture through a pad of Celite® and concentrate the filtrate in vacuo to give 3-methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine (1.42 g, 100%) that was used immediately.

Provenance & Evidence