Ether hydrochloride → HCID 131728739, compound

Participants

Reaction Conditions

Reaction Steps

Prepare the hydrochloride salt of the free base by mixing 2-(4-chloro-phenyl)-5-(3-methoxy-4-morpholin-4-yl-phenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one (273 mg, 0.599 mmol) in MeOH (4 mL) and adding a 1.0M HCl/ether (0.7 mL, 0.70 mmol) solution. After all solids dissolve, cool the solution to −20° C. for 4 days. Collect the white precipitate by filtration, wash with ether, and dry under vacuum to give the title compound as a white solid (275 mg, 57%). MS (ES+) 456.0 (M+1)+. 1H NMR (400 MHz, DMSO-d6): δ 8.05 (d, 2H, J=8.4 Hz), 7.62 (d, 2H, J=8.4 Hz), 7.18 (s, 1H), 7.12 (s, 1H), 7.00-6.96 (m, 1H), 5.69 (s, 1H), 4.10 (t, 2H, J=7.0 Hz), 3.86-3.80 (m, 7H), 3.27 (t, 2H, J=7.0 Hz), 3.20-3.12 (m, 4H).

Provenance & Evidence