反应详情

温度

40 °C

To a solution of 2-chloro-5-(3-(3-methoxy-3-oxopropyl)ureido)isonicotinic acid (33.8 g, 112 mmol) in acetone (386 mL) was added K2CO3 (46.4 g, 336 mmol) followed by CH3I (95.4 g, 672 mmol). The reaction was heated in a sealed tube at 40° C. for 24 h, cooled to RT, concentrated then diluted with EA (200 mL) and water (100 mL). The organic layer was washed with brine (100 mL), dried over Na2SO4 and concentrated to a residue which was purified by chromatography eluted with PE/EA (10:1 to 2:1) to give methyl 3-(6-chloro-1-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)propanoate (1.6 g, 11% yield) as a yellow solid. LCMS: MH+ 298 and TR=2.857 min.

1. temperaturecooled to RT
2. concentrationconcentrated
3. additionthen diluted with EA (200 mL) and water (100 mL)
4. washThe organic layer was washed with brine (100 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated to a residue which
7. customwas purified by chromatography
8. washeluted with PE/EA (10:1 to 2:1)