Ethylamine → HCID 58835358, compound

Participants

Reaction Steps

Dissolve the mixture of {2-[4-(4-azidosulfonylphenoxy)phenyl]ethyl}carbamic acid tert-butyl ester (0.291 g, 0.695 mmol) in dichloromethane (12 mL). Add TFA (12 mL) and stir at room temperature for 5 hours. Concentrate the reaction mixture. Load the product onto an SCX column with methanol. Wash the column with methanol then elute with 50% (2.0 M NH3 in methanol) in methanol to give a mixture of 2-4-(4-fluorobenzenesulfonyl)oxyphenyl)ethylamine and the title compound (0.601 g, 98.5%): MS ES+ 336.9 (M+H+18(NH4))+; TLC [silica gel 60 F254, 30% ethyl acetate, 5% (2.0 M NH3 in methanol and 65% hexanes] Rf=0.034.

Provenance & Evidence