反应详情

Methane sulfinic acid sodium salt (20.1 g, 200 mmol) is added to a stirred solution of 3,4-difluorobenzaldehyde (22.5 g, 158 miol) in dry DMSO (200 ml) at 75° C. After 2 hours the reaction is poured onto ice-water (200 ml). The precipitate is filtered, washed with water and dissolved in chloroform (400 ml). The organic extract is washed with water (2×200 ml), dried over MgSO4, filtered, and the solvent is removed to give the title compound as a white solid.

1. additionAfter 2 hours the reaction is poured onto ice-water (200 ml)
2. filtrationThe precipitate is filtered
3. washwashed with water
4. dissolutiondissolved in chloroform (400 ml)
5. extractionThe organic extract
6. washis washed with water (2×200 ml)
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customthe solvent is removed