HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 601612Generated: October 26, 2026
Imidazole → Acetamide, N-[5-[3-(1H-imidazol-1-YL)-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]-
https://huagongshe.com/reaction/601612
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamide | HCID 57351276 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Acetamide, N-[5-[3-(1H-imidazol-1-YL)-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]- | HCID 53429448 | — |
Reaction Steps
A stirred mixture of N-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (AF1) (5.0 g, 15 mmol), imidazole (2.07 g, 30 mmol) and caesium carbonate (9.93 g, 30 mmol) in dry NMP (30 ml) is heated under argon at 135° C. for 18 hours. The reaction mixture is then poured onto water (50 ml) whereupon the titled product precipitates and is recrystalfised from ethanol-water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07902375B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-8c23d3e64e344485931a955fca1f4b4f |
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| Source note | uspto-grants-2011_03 |
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