HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 601613Generated: October 26, 2026
Sodium Hydroxide → 5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine
https://huagongshe.com/reaction/601613
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Acetamide, N-[5-[3-(1H-imidazol-1-YL)-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]- | HCID 53429448 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine | HCID 57473753 | — |
Reaction Steps
N-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (AF2) (5.0 g, 13 mmol) is dissolved in 7M HCl (50 ml) and the solution is heated at 100° C. for 3 h. When cool the solution is brought to pH 8 by addition of aqueous NaOH whereupon the titled product precipitates. This is washed with ethanol followed by EtOAc, Et2O and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07902375B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-f41c8ea56385489ab263e620d8514ed2 |
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| Source note | uspto-grants-2011_03 |
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