Sodium Sulfite → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride (AG1) (16.25 g, 86.36 mmol) in dioxane (200 ml) is added dropwise a solution of sodium sulfite (16.38 g, 130 mmol) and sodium hydrogen carbonate (10.92 g, 130 mmol) in water (200 ml). The reaction mixture is heated to 70° C. for 20 minutes and then allowed to cool to room temperature. The solvent is removed in vacuo and the resultant residue is used crude in the next step.

Provenance & Evidence