反应详情

Sodium azide (10 g, 154 mmol) and ammonium chloride (3.7 g, 070 mmol) are added to a solution of 3,3-dimethyl-1,2-epoxybutane (4.26 ml, 35 mmol) in methanol:water (8:1, 315 ml), and the mixture is heated at reflux for 7 hours. The reaction is poured into ice/water (400 ml) and extracted with dichloromethane (3×200 ml). The combined organics are dried (MgSO4), filtered and evaporated to yield a clear oil (4.7 g, 94 %).

1. temperaturethe mixture is heated
2. temperatureat reflux for 7 hours
3. extractionextracted with dichloromethane (3×200 ml)
4. dry with materialThe combined organics are dried (MgSO4)
5. filtrationfiltered
6. customevaporated