Tetrahydrofuran → HCID 11175146, compound

Participants

Reaction Steps

At room temperature, 100 μl of 2M sodium hydride aqueous solution was added to 1 ml solution of tetrahydrofuran with 30 mg of 1-(2-fluoropyridine-3-yl)-4-(2-methyl-2-methylcarbonyloxy-1-oxoindane-5-yl)-5-methyl-1H-[1,2,3]triazole obtained in Example 51. The mixture was stirred at room temperature for 1 hour, diluted with ethyl acetate, washed with water and saturated saline solution, and dried with anhydrous sodium sulfate. The residues obtained by distilling out the solvents under reduced pressure were purified by silicagel column chromatography (hexane:ethyl acetate=80:20) to obtain 10 mg of the above compound as a white solid.

Provenance & Evidence