HCID 23158245, compound → HCID 23158133, compound

HRID 601667Notes

Reaction equation

HRID 601667 reaction equation
[CH3:1][N:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]3[N:13]=[N:14][N:15]([C:18]4[C:19]([F:24])=[N:20][CH:21]=[CH:22][CH:23]=4)[C:16]=3[CH3:17])[CH:8]=2)[C:3]1=[O:25].[H][H]>[C].[Pd].C(O)C>[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]3[N:13]=[N:14][N:15]([C:18]4[C:19]([F:24])=[N:20][CH:21]=[CH:22][CH:23]=4)[C:16]=3[CH3:17])[CH:8]=2)[C:3]1=[O:25]

Participants

5

Reactant 2

HCID 23158245HCID 23158245, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 23158133HCID 23158133, compoundYield 19.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

20 mg of palladium carbon was added to 10 ml solution of ethanol with 5 mg of 4-(2-methyl-1-oxo-isoquinoline-6-yl)-1-(2-fluoropyridine-3-yl)-5-methyl-1H-[1,2,3]triazole, and hydrogen was added under 4 atm of hydrogen atomosphere. 8 hours later, the reaction solution was filtered, and after distilling out the solvents of the filtrate, the residues were separated and purified by preparative thin-layer chromatography (chloroform/methanol=10/1) to obtain 1 mg of the above compound as a white solid.

Workup

  1. filtration8 hours later, the reaction solution was filtered
  2. distillationafter distilling out the solvents of the filtrate
  3. customthe residues were separated
  4. custompurified by preparative thin-layer chromatography (chloroform/methanol=10/1)

Sources & evidence

ORD record
ord-4ca1f39096184cd99379761bd964320d
Source dataset
uspto-grants-2011_03
Patent number
US07902369B2

Reaction notes

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