HCID 23158268, compound → HCID 23158202, compound

HRID 601672Notes

Reaction equation

HRID 601672 reaction equation
[CH2:1]([N:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[N:14]=[N:15][N:16]([C:19]4[C:20]([F:25])=[N:21][CH:22]=[CH:23][CH:24]=4)[C:17]=3[CH3:18])[CH:9]=2)[C:4]1=[O:26])[CH3:2].[H][H]>[C].[Pd].C(O)C>[CH2:1]([N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[N:14]=[N:15][N:16]([C:19]4[C:20]([F:25])=[N:21][CH:22]=[CH:23][CH:24]=4)[C:17]=3[CH3:18])[CH:9]=2)[C:4]1=[O:26])[CH3:2]

Participants

5

Reactant 2

HCID 23158268HCID 23158268, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 23158202HCID 23158202, compoundYield 19.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

20 mg of palladium carbon was added to 10 ml solution of ethanol with 5 mg of 4-(2-ethyl-1-oxo-isoquinoline-6-yl)-1-(2-fluoropyridine-3-yl)-5-methyl-1H-[1,2,3]triazole, hydrogen was added under 4 atm of hydrogen atmosphere. 8 hours later, the reaction solution was filtrated and after distilling out the solvents of the filtrate under reduced pressure, the residues were separated and purified by thin-layer chromatography (chloroform/methanol=10/1) to obtain 1 mg of the above compound as a white solid.

Workup

  1. filtration8 hours later, the reaction solution was filtrated
  2. distillationafter distilling out the solvents of the filtrate under reduced pressure
  3. customthe residues were separated
  4. custompurified by thin-layer chromatography (chloroform/methanol=10/1)

Sources & evidence

ORD record
ord-6bb137439bab41b09b5254f1f4de94d1
Source dataset
uspto-grants-2011_03
Patent number
US07902369B2

Reaction notes

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