反应详情

温度

140 °C

Under nitrogen atmosphere, 344 mg of 1-(2-chlorophenyl)-4-iodo-5-methyl-[1,2,3]-triazole and 276 mg of thiazolo(5,4-b)pyridine (B. Stanovnik, Synthesis, 1974, 120) were dissolved in 3 ml of DMF. Then, 100 mg of sodium acetate and 103 mg of Herrman catalyst were added, and the mixture was stirred at 140° C. for 8 hours. After diluting the reaction solution with water, the resultant was extracted with chloroform. Organic layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. The residues obtained by distilling out the solvents were separated and purified by thin-layer silicagel column chromatography (ethyl acete/hexane=1/1) to obtain 30 mg of the above compound as a white solid.

1. extractionthe resultant was extracted with chloroform
2. washOrganic layer was washed with saturated saline solution
3. dry with materialdried with anhydrous sodium sulfate
4. customThe residues obtained
5. distillationby distilling out the solvents
6. customwere separated
7. custompurified by thin-layer silicagel column chromatography (ethyl acete/hexane=1/1)