HCID 23158192, compound → HCID 58328342, compound

HRID 601684Notes

Reaction equation

HRID 601684 reaction equation
[CH:1]([N:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]3[N:15]=[N:16][N:17]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:18]=3[CH3:19])[CH:10]=2)[C:5]1=[O:26])([CH3:3])[CH3:2].[H][H]>[C].[Pd].C(O)C>[CH:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]3[N:15]=[N:16][N:17]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:18]=3[CH3:19])[CH:10]=2)[C:5]1=[O:26])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 23158192HCID 23158192, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 58328342HCID 58328342, compoundYield 91.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

After adding 50 mg of palladium carbon to 10 ml solution of ethanol with 25 mg of 4-(2-isopropyl-1-oxo-isoquinoline-6-yl)-1-(pyridine-3-yl)-5-methyl-1H-[1,2,3]triazole, hydrogen was added under 4 atm of hydrogen pressure. 8 hours later, the reaction solution was filtrated, the solvents of the filtrate were distilled outunder reduced pressure, and the residues were separated and purified by thin-layer chromatography (chloroform/methanol=10/1) to obtain 23 mg of the above compound as a white solid.

Workup

  1. filtration8 hours later, the reaction solution was filtrated
  2. distillationthe solvents of the filtrate were distilled outunder reduced pressure
  3. customthe residues were separated
  4. custompurified by thin-layer chromatography (chloroform/methanol=10/1)

Sources & evidence

ORD record
ord-ee55e5fb2b5b46ef989a3a4035478b1e
Source dataset
uspto-grants-2011_03
Patent number
US07902369B2

Reaction notes

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