Water → HCID 23158240, compound

Participants

Reaction Steps

Under nitrogen atmosphere, 50 mg of 5-bromo-2-(2-hydroxy-2-methyl-propyl)-1-oxo-isoindoline obtained in Example 177-1) was dissolved in tetrahydrofuran. 21 mg of acetatic anhydride and 20 mg of sodium hydride were added and the mixture was heated under reflux for 4 hours. The reaction solution was cooled down to room temperature, water was added and the products were extracted with ethyl acetate. Ethyl acetate layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. The solvents were distilled outunder reduced pressure, and the residues were separated and purified by silicagel column chromatography (ethyl acetate/hexane=1/2) to obtain 44 mg of the above compound as a white solid.

Provenance & Evidence