Trifluoroacetic acid → HCID 67271991, compound

Participants

Reaction Steps

A solution of (R)-tert-butyl 3-((4S,5S)-4-(3,5-difluorobenzyl)-2-oxooxazolidin-5-yl)-8-(triisopropylsilyloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (Step F (11), 470 mg) in CH2Cl2 (20 mL) was treated with TFA (5 mL). This reaction mixture was stirred at rt for 3 h. The mixture was then concentrated in vacuo. Ethyl acetate (10 mL) was added and removed and toluene (10 mL) was added and removed twice to give the title compound: 1H NMR (CDCl3, 500 MHz) δ 1.10 (18H, m), 1.30 (3H, m), 2.61-2.66 (2H, m), 3.08 (1H, dd, J=5, 15 Hz), 3.18 (1H, m), 3.36 (1H, m), 3.79 (1H, d, J=20 Hz), 4.05-4.09 (1H, m), 4.14 (1H, d, J=20 Hz), 4.39 (1H, m), 5.54 (1H, s), 6.64 (1H, d, J=5 Hz), 6.69-6.72 (2H, m), 6.78 (2H, m), 7.01 (1H, m). MS (ESI) (M+H)+ 517.11.

Provenance & Evidence