HCID 67271708, compound → HCID 67271814, compound

Participants

Reaction Steps

To a solution of the compound of Step (A) in MeOH was added 10% Pd/C. The mixture was shaken under H2 in a Parr shaker, and after 3 pump/flush cycles, the reaction was allowed to shake overnight. The reaction was filtered through a 0.45 μm filter, and solvents removed in vacuo. The residue was injected onto a reverse-phase HPLC column (XTERRA S5 19×100 mm, gradient from 10% MeOH/H2O to 90% MeOH/H2O, containing 0.1% TFA) to afford, after solvent removal, pure product. 1H NMR (500 MHz, CD3OD) δ ppm 0.93 (t, J=7.02 Hz, 3H) 1.08-1.22 (m, 1H) 1.24-1.46 (m, 5H) 1.64-1.78 (m, 1H) 1.78-1.99 (m, 2H) 1.99-2.12 (m, 1H) 2.20-2.44 (m, 3H) 2.77 (dd, J=14.04, 11.29 Hz, 1H) 2.98-3.09 (m, 1H) 3.11-3.23 (m, 2H) 3.23-3.43 (m, 2H) 3.51-3.60 (m, 1H) 4.03 (dd, J=9.77, 2.14 Hz, 1H) 4.17-4.48 (m, 4H) 6.73-6.82 (m, 1H) 6.82-6.92 (m, 4H) 7.06-7.32 (m, 7H). HPLC retention time: 1.84 min (method C). MS (ESI) (M+H)+ 604.

Provenance & Evidence