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温度

0 °C

Pyridine (0.28 ml) and thionyl chloride (0.18 ml) were added successively to an ice-cold solution of the intermediate from step A (0.64 g, 2.0 mmol) in dichloromethane (20 ml). The reaction mixture was stirred at 0° C. for 1 h and then saturated ammonium chloride solution was added. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude intermediate was rapidly employed without further purification in the next step.

1. dry with materialThe organic phase was dried over magnesium sulfate
2. filtrationfiltered
3. concentrationconcentrated under reduced pressure
4. customThe crude intermediate was rapidly employed without further purification in the next step