反应详情

3.2 g (10 mmol) of the intermediate from step B were suspended in 40 ml CH2Cl2. 50 ml of a 2M solution of NH3 in ethanol were added and the reaction mixture was stirred for 16 h at ambient temperature. The mixture was poured into an ice/water mixture and the precipitate was separated. The precipitate was redissolved in ethyl acetate. This organic phase was washed with 2M aqueous HCl. The aqueous phase was made alkaline (pH=8-9) and then extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and the solvent was removed in vacuo to yield 1.7 g of the intermediate.

1. customthe precipitate was separated
2. dissolutionThe precipitate was redissolved in ethyl acetate
3. washThis organic phase was washed with 2M aqueous HCl
4. extractionextracted with ethyl acetate
5. dry with materialThe organic phase was dried over magnesium sulfate
6. customthe solvent was removed in vacuo