Lithium hydroxide, monohydrate → 4-Oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

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Reaction Steps

The title compound was synthesized from methyl 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (11 mg, 0.06 mmol) and lithium hydroxide monohydrate (10 mg, 0.25 mmol) according to General Procedure 7 (6.8 mg, 67%). 1H NMR (400 MHz, METHANOL-d4) δ ppm 2.89-2.93 (m, 2H), 2.98-3.02 (m, 2H), 6.89 (s, 1H); LCMS-MS (ESI+) 163.7 (M−H); HPLC (UV=100%).

Provenance & Evidence