Lithium hydroxide, monohydrate → HCID 44125114, compound

Participants

Reaction Steps

The title compound was synthesized from methyl 4-isopropyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (0.09 g, 0.43 mmol) and lithium hydroxide monohydrate (185 mg, 4.3 mmol) according to General Procedure 7. The crude product was dried onto Silica gel and was purified by chromatography (0 to 100% EtOAc/heptane) to give 4-isopropyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (10) as brown solid (0.018 g, 21%). 1H NMR (400 MHz, METHANOL-d4) δ ppm 0.93 (d, J=2.68 Hz, 3H) 0.95 (d, J=2.68 Hz, 3H) 1.67 (dq, J=13.37, 6.67 Hz, 1H) 2.04-2.14 (m, J=12.81, 8.91, 5.71, 5.71 Hz, 1H) 2.44-2.55 (m, 1H) 2.56-2.80 (m, 3H) 6.63 (s, 1H). LCMS m/e 194 (M+H). 92.0% pure by HPLC.

Provenance & Evidence