Lithium hydroxide, monohydrate → HCID 44125122, compound

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Reaction Steps

The title compound was synthesized from methyl 4-(4-methoxyphenethyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (235 mg, 0.78 mmol) and lithium hydroxide monohydrate (132 mg, 3.14 mmol) according to General Procedure 7. Silica gel was added, the solvent stripped off and the silica gel-imbedded material was purified by flash chromatography (0-80% EtOAc/Heptane) to give 4-(4-methoxyphenethyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (34) as a light yellow solid (142 mg, 63%). 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.64-1.84 (m, 2H), 1.96-2.08 (m, 1H), 2.53-2.78 (m, 5H), 2.85-2.97 (m, 1H), 3.75 (s, 3H), 6.67 (s, 1H), 6.77-6.86 (m, 2H), 7.06-7.16 (m, 2H); LCMS-MS (ESI+) 286.1 (M+H); HPLC (UV=100%), (ELSD=100%).

Provenance & Evidence