Lithium hydroxide, monohydrate → HCID 59180136, compound

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Reaction Steps

The title compound was synthesized from methyl 4-(2-methyl-2-phenylpropyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (0.10 g, 0.33 mmol) and lithium hydroxide monohydrate (142 mg, 3.3 mmol) according to General Procedure 7. Silica gel was added, the solvent stripped off and the silica gel-imbedded material was purified by flash chromatography (0-100% EtOAc/Heptane) to give 4-(2-methyl-2-phenylpropyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (35) as a reddish brown solid (2.4 mg).

Provenance & Evidence