Hydrochloric Acid → 7-Methoxy-4-(oxan-2-yl)-4,5,10,12-tetraazatetracyclo[6.6.1.02,6.011,15]pentadeca-1(15),2,5,8,11,13-hexaene

Participants

Reaction Steps

To a stirred solution of 1-(oxan-2-yl)-4-{1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazole-3-carbaldehyde (1.88 g, 6.35 mmol) in MeOH (280 mL, a concentration of 0.023 mol/L), was added KOH (3.56 g, 27.68 mmol). The reaction mixture was stirred at room temperature for 42 hours. When TLC showed completion of reaction, the pH was adjusted to 7 by addition of HCl (4 M in MeOH).

Provenance & Evidence