Lithium hydroxide, monohydrate → HCID 44125253, compound

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The title compound was synthesized from methyl 5-benzyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (0.017 g, 0.065 mmol) and lithium hydroxide monohydrate (0.019 g, 0.45 mmol) according to General Procedure 7. The crude product was purified by reverse phase HPLC (40-100% MeOH: water, 0.1% formic acid), to give 5-benzyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (23) as a light brown solid (6.1 mg, 39%). Rf (1:1 EtOAc:heptane)=0.12; 1H NMR (400 MHz, METHANOL-d4) δ ppm 2.30-2.49 (m, 2H), 2.62-2.90 (m, 4H), 3.08-3.20 (m, 1H), 6.57 (s, 1H), 7.16-7.30 (m, 5H); LCMS-MS (ESI+) 242.3 (M+H); HPLC (UV=100%), (ELSD=100%).

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