反应详情

温度

80 °C

Under argon, 3.03 g (12.10-3 mol) of 3-cyano-4-iodobenzonitrile and 3.36 g (48.10-3 mol) of sodium thiomethylate are dissolved in 80 ml of anhydrous hexamethylphosphoramide and the solution obtained is then heated at 80° C. for 45 minutes. The resulting reaction medium is hydrolyzed in an ice/1N HCl mixture and then extracted with methylene chloride. The organic phase is washed with water and then dried over magnesium sulfate and evaporated under reduced pressure to give 1.55 g (yield: 81%) of the expected product.

1. customthe solution obtained
2. customThe resulting reaction medium
3. extractionextracted with methylene chloride
4. washThe organic phase is washed with water
5. dry with materialdried over magnesium sulfate
6. customevaporated under reduced pressure