反应详情

To 30 ml of ethanol were added 5.5 g of methyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 10 ml of 15% aqueous sodium hydroxide solution and the mixture obtained was stirred at room temperature for 2 hours. Then, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue for acidification and then, solid precipitated was collected by filtration to obtain 5.0 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid represented by the formula:

1. customthe mixture obtained
2. concentrationThen, the reaction mixture was concentrated under reduced pressure
3. additionHydrochloric acid was added to the residue for acidification
4. customsolid precipitated
5. filtrationwas collected by filtration