Sodium Hydroxide → 3,5-Difluoro-4-(2-propynyloxy)benzoic acid

HRID 602022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 602022
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:16])[C:11]=1[O:12][CH2:13][C:14]#[CH:15])[C:5]([O:7]C)=[O:6].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:16])[C:11]=1[O:12][CH2:13][C:14]#[CH:15])[C:5]([OH:7])=[O:6]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 57445723Methyl 3,5-difluoro-4-(2-propynyloxy)benzoate

Produkt 1

HCID 574456663,5-Difluoro-4-(2-propynyloxy)benzoic acidAusbeute 96,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 30 ml of ethanol were added 5.5 g of methyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 10 ml of 15% aqueous sodium hydroxide solution and the mixture obtained was stirred at room temperature for 2 hours. Then, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue for acidification and then, solid precipitated was collected by filtration to obtain 5.0 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid represented by the formula:

Aufarbeitung

  1. customthe mixture obtained
  2. concentrationThen, the reaction mixture was concentrated under reduced pressure
  3. additionHydrochloric acid was added to the residue for acidification
  4. customsolid precipitated
  5. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-bef77c09df57428a9a1eef62660e54c9
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902400B2

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