HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfite → 3,5-Difluoro-4-(2-propynyloxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 3,5-Difluoro-4-(2-propynyloxy)benzaldehyde | HCID 57445667 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,5-Difluoro-4-(2-propynyloxy)benzoic acid | HCID 57445666 | 184.9% |
Reaction Steps
To 100 ml of chloroform were added 20 g of 3,5-difluoro-4-(2-propynyloxy)benzaldehyde and 25 g of 3-chloroperbenzoic acid and the mixture obtained was stirred at room temperature for overnight. Then, aqueous sodium sulfite solution was added to the reaction mixture and extracted with chloroform and ethyl acetate in order. The organic layers were combined, dried over magnesium sulfate and concentrated under reduced pressure to obtain 40 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902400B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-6401ec2c109e4ebe9049965cefeb5553 |
| Source note | uspto-grants-2011_03 |