HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 602043Generated: October 31, 2026
Potassium Carbonate → Ethyl 3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-1-hydroxyethyl)-4,5-difluorophenyl]propanoate
https://huagongshe.com/reaction/602043
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-amine | HCID 9834173 | — |
| Reactant | Ethyl 3-{3,4-difluoro-5-[(1S)-1-hydroxy-2-iodoethyl]phenyl}propanoate | HCID 68794275 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-[3-((1S)-2-{[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino}-1-hydroxyethyl)-4,5-difluorophenyl]propanoate | HCID 24957326 | 49.4% |
Reaction Steps
To a solution of ethyl 3-{3,4-difluoro-5-[(1S)-1-hydroxy-2-iodoethyl]phenyl}propanoate (0.550 g, 1.43 mmol) in ethanol (2.8 mL) was added [2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amine (0.273 g, 1.44 mmol) and K2CO3 (0.218 g, 1.58 mmol). The reaction was heated at 90° C. for 17 h. Upon cooling, the reaction was filtered and concentrated. Column chromatography (0-12% CH3OH:CH2Cl2) provided 0.315 g (49%) of the title compound: MS (ESI) 446.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07902394B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-ad3c8f8852f049b9864c4c03f10171ec |
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| Source note | uspto-grants-2011_03 |
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