2-Methyl-5-phenylpentan-2-amine → Ethyl 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)pentanoate

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Reaction Steps

Ethyl 3-{3,4-difluoro-5-[(2S)-2-oxiranyl]phenyl}pentanoate (8.56 g, 0.0301 mol) and (1,1-dimethyl-4-phenylbutyl)amine (5.39 g, 0.0304 mol) in ethanol (50 mL) was heated at 70° C. overnight. The reaction was concentrated and purified by column chromatography (0-40% ethyl acetate:hexane) yield the desired product (9.53 g, 69%). MS (m/z): 434.2 (M+H).

Provenance & Evidence