HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 6-(2,5-Difluorophenyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 6-(2,5-difluorophenyl)nicotinate | HCID 67267400 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(2,5-Difluorophenyl)nicotinic acid | HCID 24729984 | 97% |
Reaction Steps
To tert-butyl 6-(2,5-difluorophenyl)nicotinate in DCM (12 mL) at 0° C. was added TFA (5 mL). After stirring at room temperature overnight, toluene was added (10 mL) and the solvent removed to give a white solid (176 mg, 97%), 6-(2,5-difluorophenyl)nicotinic acid. LC/MS (M+H)=236.0 observed, 236.05 expected
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902373B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-9bf8c0e5796c4a6a877aa5376e4af6bd |
| Source note | uspto-grants-2011_03 |