1-(Benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine → Tert-butyl-dimethyl-(3-piperidylmethoxy)silane

Participants

Reaction Steps

10% palladium on activated carbon (1.32 g) was added to 1-(benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine (13.2 g, 36.3 mmol) in methanol (130 mL). The mixture was stirred at room temperature for 1 hour in a hydrogen atmosphere. Subsequently, the mixture was filtered through Celite, followed by evaporation of the solvent to give 7.96 g (96%) of the desired compound as a colorless oil.

Provenance & Evidence