反应详情

4-Benzylmorpholine-2-carboxylic acid hydrochloride (1.00 g, 3.88 mmol) in a 10 (w/w) % hydrochloric acid/methanol solution (20 mL) was stirred at room temperature for 2 hours. The solvent was evaporated and a saturated aqueous sodium bicarbonate solution was added to the residue to make the mixture basic. The mixture was then extracted with ethyl acetate and the extract washed with brine and was dried over magnesium sulfate. Evaporation of the solvent gave 730 mg (80%) of the desired compound as a colorless oil.

1. customThe solvent was evaporated
2. additiona saturated aqueous sodium bicarbonate solution was added to the residue
3. extractionThe mixture was then extracted with ethyl acetate
4. washthe extract washed with brine
5. dry with materialwas dried over magnesium sulfate
6. customEvaporation of the solvent