HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidine → Methyl 3-[3-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidin-1-yl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidine | HCID 57572215 | — |
| Reactant | 3-Methoxycarbonylphenylboric acid | HCID 67170287 | — |
| Product | Methyl 3-[3-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidin-1-yl]benzoate | HCID 58992679 | 79.4% |
Reaction Steps
Using 3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidine (62.2 mg, 0.185 mmol) and 3-(methoxycarbonyl)phenylboric acid (66.6 mg, 0.370 mmol), the same procedure was followed as in Example 2 to obtain 69.2 mg (79%) of the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-f0c75d01800343d398242ac8c7ec85bc |
| Source note | uspto-grants-2011_03 |