HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(perhydroazepin-3-yl methyl)-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide → Methyl 3-[3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]carbonylaminomethyl]perhydroazepin-1-yl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(perhydroazepin-3-yl methyl)-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide | HCID 58992626 | — |
| Reactant | 3-Methoxycarbonylphenylboric acid | HCID 67170287 | — |
| Product | Methyl 3-[3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]carbonylaminomethyl]perhydroazepin-1-yl]benzoate | HCID 58992589 | 46% |
Reaction Steps
Using N-(perhydroazepin-3-yl methyl)-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide (200 mg, 0.550 mmol) and 3-(methoxycarbonyl)phenylboric acid (198 mg, 1.10 mmol), the same procedure was followed as in Example 2 to give 126 mg (46%) of the desired compound as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b70b330a14b742448e61da4e030d5140 |
| Source note | uspto-grants-2011_03 |