5-Thiazoleacetic acid, 2-(p-chlorophenyl)-4-methyl- → HCID 58992593, compound

HRID 602150Notes

Reaction equation

HRID 602150 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:14][C:15]([OH:17])=O)=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH2:28][CH:27]([NH2:31])[CH2:26]1)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH2:28][CH:27]([NH:31][C:15](=[O:17])[CH2:14][C:10]2[S:9][C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)=[N:12][C:11]=2[CH3:13])[CH2:26]1)=[O:24])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 288595-Thiazoleacetic acid, 2-(p-chlorophenyl)-4-methyl-HCID 5458091-BOC-3-Aminopiperidine

Product 1

HCID 58992593HCID 58992593, compoundYield 59%

Procedure

Using 2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]acetic acid (1.60 g, 5.99 mmol) and 1-(tert-butoxycarbonyl)-3-aminopiperidine (1.20 g, 5.99 mmol), the same procedure was followed as in Step 1a of Example 1 to give 1.59 g (59%) of the desired compound as a colorless powder.

Sources & evidence

ORD record
ord-94b9830a18804163b5e5078b7bfb9111
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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