Potassium Hydroxide → 2-[3-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]carbonylaminomethyl]piperidin-1-yl]benzoic acid

Participants

Reaction Steps

Methyl 2-[3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]carbonylaminomethyl]piperidin-1-yl]benzoate (29.5 mg, 0.0609 mmol) was dissolved in methanol (3 mL). To this solution, a 1 mol/L aqueous potassium hydroxide solution (0.183 mL, 0.183 mmol) was added and the mixture was stirred for 2 hours while being refluxed. Subsequently, the reaction mixture was concentrated and water was added to the residue, followed by 2 mol/L hydrochloric acid to make the mixture acidic. The crystallized powdery product was collected by filtration and washed with water to give 23.2 mg (81%) of the desired product as a colorless powder.

Provenance & Evidence