Water → HCID 43590388, compound

Participants

Reaction Conditions

Reaction Steps

2-Fluorobenzaldehyde (3.26 mL, 30.0 mmol), potassium carbonate (5.64 g, 40.0 mmol) and tetrabutylammonium iodide (739 mg, 2.00 mmol) were added to 3-piperidylmethanol (2.30 g, 20.0 mmol) in N,N-dimethylformamide (20 mL). The reaction mixture was stirred at 130° C. for 8 hours. Subsequently, water was added and the mixture was extracted with ethyl acetate. The extract was washed with brine, followed by drying over magnesium sulfate and evaporation of the solvent. Purification of the resulting residue by silica gel column chromatography (hexane:ethyl acetate=5:1->1:1) gave 1.56 g (36%) of the desired compound as a yellow oil.

Provenance & Evidence