[4-(4-Chlorophenyl)phenyl]methylamine hydrochloride → Methyl 2-[3-[N-[(4'-chlorobiphenyl-4-yl)methyl]carbamoyl]piperidin-1-yl]benzoate

Participants

Reaction Steps

Using 1-[2-(methoxycarbonyl)phenyl]nipecotic acid (77.5 mg, 0.294 mmol) and (4′-chlorobiphenyl-4-yl)methylamine hydrochloride (72.2 mg, 0.284 mmol), the same procedure was followed as in Step 3a of Example 3 to give 114 mg (87%) of the desired compound as a colorless amorphous product.

Provenance & Evidence