Benzyl piperidine-3-carboxylate → 1-[3-(Methoxycarbonyl)phenyl]benzyl nipecotate

HRID 602170Notes

Reaction equation

HRID 602170 reaction equation
[NH:1]1[CH2:16][CH2:15][CH2:14][CH:3]([C:4]([O:6][CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])[CH2:2]1.[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23](OB(O)O)[CH:24]=[CH:25][CH:26]=1)=[O:20]>>[NH:1]1[CH2:16][CH2:15][CH2:14][CH:3]([C:4]([O:6][CH2:7][C:8]2([C:25]3[CH:24]=[CH:23][CH:22]=[C:21]([C:19]([O:18][CH3:17])=[O:20])[CH:26]=3)[CH:13]=[CH:12][CH:11]=[CH:10][CH2:9]2)=[O:5])[CH2:2]1

Participants

3

Reactant 2

HCID 13419237Benzyl piperidine-3-carboxylateHCID 671702873-Methoxycarbonylphenylboric acid

Product 1

HCID 866158861-[3-(Methoxycarbonyl)phenyl]benzyl nipecotateYield 33%

Procedure

Using benzyl nipecotate (4.39 g, 20.0 mmol) and 3-methoxycarbonylphenylboric acid (7.20 g, 40.0 mmol), the same procedure was followed as in Example 2 to give 2.34 g (33%) of the desired compound as a colorless oil.

Sources & evidence

ORD record
ord-9ac1bf5e996a4fd4ab204c8465ea457a
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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