HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((Tert-butoxy)carbonyl)piperidine-3-carboxylic acid → 1-(tert-Butoxycarbonyl)-N-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]piperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((Tert-butoxy)carbonyl)piperidine-3-carboxylic acid | HCID 2735647 | — |
| Reactant | 5-Amino-2-(4-chlorophenyl)-4-methylthiazole | HCID 67267329 | — |
| Product | 1-(tert-Butoxycarbonyl)-N-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]piperidine-3-carboxamide | HCID 58992608 | 30.1% |
Reaction Steps
Using 5-amino-2-(4-chlorophenyl)-4-methylthiazole (197 mg, 0.877 mmol) and 1-(tert-butoxycarbonyl)nipecotic acid (205 mg, 0.877 mmol), the same procedure was followed as in Step 3a of Example 3 to give 115 mg (30%) of the desired compound as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-d329f90d64b24054b4c93333eed29394 |
| Source note | uspto-grants-2011_03 |