HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-3-hydroxypiperidine → 1-(tert-Butoxycarbonyl)-3-[(4'-chlorobiphenyl-4-yl)methoxy]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-3-hydroxypiperidine | HCID 545699 | — |
| Reactant | 4'-Chloro-4-chloromethylbiphenyl | HCID 12773846 | — |
| Product | 1-(tert-Butoxycarbonyl)-3-[(4'-chlorobiphenyl-4-yl)methoxy]piperidine | HCID 58992680 | 84% |
Reaction Steps
Using 1-(tert-butoxycarbonyl)-3-hydroxypiperidine (403 mg, 2.00 mmol) and 4′-chloro-4-chloromethylbiphenyl (474 mg, 2.00 mmol), the same procedure was followed as in Step 6a of Example 6 to give 672 mg (84%) of the desired compound as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-aac6f53a90d446a4aadf87b1adb8ad31 |
| Source note | uspto-grants-2011_03 |