3-[(4′-Chloro[1,1′-biphenyl]-4-yl)methoxy]piperidine → HCID 58992599, compound

HRID 602179Notes

Reaction equation

HRID 602179 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][O:15][CH:16]3[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:22][O:23][C:24]([C:26]1[CH:27]=[C:28](OB(O)O)[CH:29]=[CH:30][CH:31]=1)=[O:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][O:15][CH:16]3[CH2:21][CH2:20][CH2:19][N:18]([C:30]4[CH:31]=[C:26]([CH:27]=[CH:28][CH:29]=4)[C:24]([O:23][CH3:22])=[O:25])[CH2:17]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 589926553-[(4′-Chloro[1,1′-biphenyl]-4-yl)methoxy]piperidineHCID 671702873-Methoxycarbonylphenylboric acid

Product 1

HCID 58992599HCID 58992599, compoundYield 34%

Procedure

Using 3-[(4′-chlorobiphenyl-4-yl)methoxy]piperidine (220 mg, 0.729 mmol) and 3-(methoxycarbonyl)phenylboric acid (263 mg, 1.46 mmol), the same procedure was followed as in Example 2 to give 107 mg (34%) of the desired compound as a colorless oil.

Sources & evidence

ORD record
ord-f8f6b2cdb55a4d9f960defef0c7057e3
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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