tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate → 1-(tert-Butoxycarbonyl)-3-[(4'-chlorobiphenyl-4-yl)methoxymethyl]piperidine

Participants

Reaction Steps

Using 1-(tert-butoxycarbonyl)-piperidin-3-yl methanol (431 mg, 2.00 mmol) and 4′-chloro-4-chloromethylbiphenyl (474 mg, 2.00 mmol), the same procedure was followed as in Step 5a of Example 5 to give 711 mg (86%) of the desired compound as a colorless oil.

Provenance & Evidence