HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Fluorophenoxy)benzylchloride → 1-Trifluoroacetyl-3-[[4-(4-fluorophenoxy)phenyl]methoxymethyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Fluorophenoxy)benzylchloride | HCID 22293136 | — |
| Reactant | 1-Trifluoroacetylpiperidin-3-yl methanol | HCID 58992664 | — |
| Product | 1-Trifluoroacetyl-3-[[4-(4-fluorophenoxy)phenyl]methoxymethyl]piperidine | HCID 58992699 | 13.4% |
Reaction Steps
Using 1-trifluoroacetylpiperidin-3-yl methanol (422 mg, 2.00 mmol) and 4-(4-fluorophenoxy)benzylchloride (473 mg, 2.00 mmol), the same procedure was followed as in Step 5a of Example 5 to give 110 mg (13%) of the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-92336aba4f7f491e925d9dc9043b287a |
| Source note | uspto-grants-2011_03 |