HCID 58992653, compound → HCID 58992637, compound

HRID 602193Notes

Reaction equation

HRID 602193 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14](=[O:22])[CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]3)=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[CH3:23][O:24][C:25]([C:27]1[CH:28]=[C:29](OB(O)O)[CH:30]=[CH:31][CH:32]=1)=[O:26]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14](=[O:22])[CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][N:18]([C:31]4[CH:32]=[C:27]([CH:28]=[CH:29][CH:30]=4)[C:25]([O:24][CH3:23])=[O:26])[CH2:17]3)=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58992653HCID 58992653, compoundHCID 671702873-Methoxycarbonylphenylboric acid

Product 1

HCID 58992637HCID 58992637, compoundYield 45.2%

Procedure

Using 3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]-2-oxoethyl]piperidine (140 mg, 0.418 mmol) and 3-(methoxycarbonyl)phenylboric acid (150 mg, 0.836 mmol), the same procedure was followed as in Example 2 to give 88.7 mg (45%) of the desired compound as a yellow oil.

Sources & evidence

ORD record
ord-5e85ea2d97f6424ebe8b4c80257f45ff
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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